Inhibition of factor VIII with a partially inhibitory human recombinant monoclonal antibody prevents thrombotic events in a transgenic model of type II HBS antithrombin deficiency in mice.

Dewerchin, M; Van der Elst, L; Singh, I; Grailly, S; Saint-Remy, J-M; Collen, D; Jacquemin, M

Dewerchin, M; Van der Elst, L; Singh, I; Grailly, S; Saint-Remy, J-M; Collen, D; Jacquemin, M.

Affiliation

Dewerchin M; Center for Transgene Technology and Gene Therapy, VIB, KULeuven Campus Gasthuisberg, Leuven, Belgium. mieke.dewerchin@med.kuleuven.ac.be

J Thromb Haemost ; 2(1): 77-84, 2004 Jan.

Article in En | MEDLINE | ID: mdl-14717970

Subject(s)

Antibodies, Monoclonal/pharmacology; Antithrombin III Deficiency/drug therapy; Factor VIII/antagonists & inhibitors; Fibrinolytic Agents/pharmacology; Thrombosis/prevention & control; Animals; Antibodies, Monoclonal/pharmacokinetics; Antithrombin III/genetics; Antithrombin III Deficiency/blood; Antithrombin III Deficiency/genetics; Binding Sites/genetics; Factor VIII/immunology; Female; Fibrinolytic Agents/pharmacokinetics; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Priapism/etiology; Priapism/pathology; Priapism/prevention & control; Recombinant Proteins/pharmacokinetics; Recombinant Proteins/pharmacology; Thrombosis/etiology; Thrombosis/pathology

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Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Thrombosis / Factor VIII / Antithrombin III Deficiency / Fibrinolytic Agents / Antibodies, Monoclonal Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Thromb Haemost Year: 2004 Document type: Article

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