Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice.

Wolf, Kristina K; Wood, Sheryl G; Bement, Jenna L; Sinclair, Peter R; Wrighton, Steven A; Jeffery, Elizabeth; Gonzalez, Frank J; Sinclair, Jacqueline F

Wolf, Kristina K; Wood, Sheryl G; Bement, Jenna L; Sinclair, Peter R; Wrighton, Steven A; Jeffery, Elizabeth; Gonzalez, Frank J; Sinclair, Jacqueline F.

Affiliation

Wolf KK; Veterans Administration Medical Center, White River Junction, VT 05009, USA.

Drug Metab Dispos ; 32(7): 681-4, 2004 Jul.

Article in En | MEDLINE | ID: mdl-15205381

Subject(s)

Cytochrome P-450 CYP2E1/metabolism; Microsomes, Liver/metabolism; Nitrophenols/metabolism; Animals; Aryl Hydrocarbon Hydroxylases/biosynthesis; Aryl Hydrocarbon Hydroxylases/metabolism; Cytochrome P-450 CYP2E1/biosynthesis; Cytochrome P-450 CYP2E1/genetics; Cytochrome P-450 CYP3A; Enzyme Induction; Ethanol/pharmacology; Female; Hydroxylation; In Vitro Techniques; Male; Mice; Mice, Knockout; Microsomes, Liver/enzymology; Oxidoreductases, N-Demethylating/biosynthesis; Oxidoreductases, N-Demethylating/metabolism; Pentanols/pharmacology; Sex Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Cytochrome P-450 CYP2E1 / Nitrophenols Type of study: Prognostic_studies Limits: Animals Language: En Journal: Drug Metab Dispos Year: 2004 Document type: Article

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