Treatment intensity significantly influencing fibrosis in bone marrow independently of the cytogenetic response: meta-analysis of the long-term results from two prospective controlled trials on chronic myeloid leukemia.

Buesche, G; Freund, M; Hehlmann, R; Georgii, A; Ganser, A; Hecker, H; Heimpel, H; Fonatsch, C; Heinze, B; Pfirrmann, M; Holgado, S; Schmeil, A; Tobler, A; Hasford, J; Buhr, T; Kreipe, H-H

Buesche, G; Freund, M; Hehlmann, R; Georgii, A; Ganser, A; Hecker, H; Heimpel, H; Fonatsch, C; Heinze, B; Pfirrmann, M; Holgado, S; Schmeil, A; Tobler, A; Hasford, J; Buhr, T; Kreipe, H-H.

Affiliation

Buesche G; Institut für Pathologie, Medizinische Hochschule Hannover, Germany. Guntram.Buesche@epost.de

Leukemia ; 18(9): 1460-7, 2004 Sep.

Article in En | MEDLINE | ID: mdl-15284854

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Bone Marrow/pathology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology; Primary Myelofibrosis/etiology; Adult; Biopsy; Chromosome Aberrations; Controlled Clinical Trials as Topic; Cytarabine/administration & dosage; Cytogenetic Analysis; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Interferon-alpha/administration & dosage; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/mortality; Male; Middle Aged; Prospective Studies; Risk Factors; Survival Rate

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Collection: 01-internacional Health context: 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Bone Marrow / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Antineoplastic Combined Chemotherapy Protocols / Primary Myelofibrosis Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Leukemia Year: 2004 Document type: Article

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