Stem cells and cancer; the polycomb connection.

Valk-Lingbeek, Merel E; Bruggeman, Sophia W M; van Lohuizen, Maarten

Valk-Lingbeek, Merel E; Bruggeman, Sophia W M; van Lohuizen, Maarten.

Affiliation

Valk-Lingbeek ME; The Netherlands Cancer Institute, Department of Molecular Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Cell ; 118(4): 409-18, 2004 Aug 20.

Article in En | MEDLINE | ID: mdl-15315754

ABSTRACT

ABSTRACT

Proteins from the Polycomb group (PcG) are epigenetic chromatin modifiers involved in cancer development and also in the maintenance of embryonic and adult stem cells. The therapeutic potential of stem cells and the growing conviction that tumors contain stem cells highlights the importance of understanding the extrinsic and intrinsic circuitry controlling stem cell fate and their connections to cancer.

Subject(s)

Neoplasms/pathology; Stem Cells/cytology; Animals; Cell Differentiation; Cell Line; Chromatin/metabolism; Cyclin-Dependent Kinase Inhibitor p16/metabolism; Drosophila; Embryo, Mammalian/cytology; Embryo, Nonmammalian; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/metabolism; Histones/metabolism; Humans; Models, Biological; Neoplasms/metabolism; Neurons/metabolism; Nuclear Proteins/metabolism; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Proto-Oncogene Proteins/metabolism; Repressor Proteins/metabolism; Stem Cells/metabolism; Up-Regulation

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Year: 2004 Document type: Article

Search on Google

XML

PubMed Links