Angiogenesis Inhibitors/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Histone Deacetylase Inhibitors; Hydroxamic Acids/pharmacology; Phthalazines/pharmacology; Pyridines/pharmacology; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors; Angiogenesis Inhibitors/administration & dosage; Animals; Cattle; Cell Division/drug effects; Cell Line, Tumor; Drug Synergism; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/pharmacology; Gene Expression Regulation/drug effects; Humans; Hydroxamic Acids/administration & dosage; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Neovascularization, Pathologic/drug therapy; Neovascularization, Pathologic/enzymology; Neovascularization, Pathologic/genetics; Phthalazines/administration & dosage; Pyridines/administration & dosage; Transcription Factors/biosynthesis; Vascular Endothelial Growth Factor A/biosynthesis; Xenograft Model Antitumor Assays