Structural characterization of the cell wall binding domains of Clostridium difficile toxins A and B; evidence that Ca2+ plays a role in toxin A cell surface association.

Demarest, Stephen J; Salbato, Jared; Elia, Marikka; Zhong, Jingping; Morrow, Theresa; Holland, Trevin; Kline, Katie; Woodnutt, Gary; Kimmel, Bruce E; Hansen, Geneviève

Demarest, Stephen J; Salbato, Jared; Elia, Marikka; Zhong, Jingping; Morrow, Theresa; Holland, Trevin; Kline, Katie; Woodnutt, Gary; Kimmel, Bruce E; Hansen, Geneviève.

Affiliation

Demarest SJ; Department of Protein Therapeutics, Diversa Corp., 4955 Directors Place, San Diego, CA 92121, USA. stephen.demarest@biogenidec.com

J Mol Biol ; 346(5): 1197-206, 2005 Mar 11.

Article in En | MEDLINE | ID: mdl-15713474

Subject(s)

Bacterial Proteins/chemistry; Bacterial Toxins/chemistry; Calcium/metabolism; Cell Wall/metabolism; Clostridioides difficile; Enterotoxins/chemistry; Amino Acid Sequence; Animals; Apoptosis; Bacterial Proteins/metabolism; Bacterial Proteins/toxicity; Bacterial Toxins/metabolism; Bacterial Toxins/toxicity; CHO Cells; Cloning, Molecular; Cricetinae; Enterotoxins/metabolism; Enterotoxins/toxicity; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Streptococcus pneumoniae

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Bacterial Toxins / Cell Wall / Calcium / Clostridioides difficile / Enterotoxins Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Mol Biol Year: 2005 Document type: Article

Search on Google

XML

PubMed Links