Toward a novel class of antithrombotic compounds with dual function. Discovery of 1,4-benzoxazin-3(4H)-one derivatives possessing thrombin inhibitory and fibrinogen receptor antagonistic activities.

Stefanic Anderluh, Petra; Anderluh, Marko; Ilas, Janez; Mravljak, Janez; Sollner Dolenc, Marija; Stegnar, Mojca; Kikelj, Danijel

Stefanic Anderluh, Petra; Anderluh, Marko; Ilas, Janez; Mravljak, Janez; Sollner Dolenc, Marija; Stegnar, Mojca; Kikelj, Danijel.

Affiliation

Stefanic Anderluh P; University of Ljubljana, Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia.

J Med Chem ; 48(9): 3110-3, 2005 May 05.

Article in En | MEDLINE | ID: mdl-15857114

Subject(s)

Anticoagulants/chemical synthesis; Benzoxazines/chemical synthesis; Fibrinolytic Agents/chemical synthesis; Platelet Aggregation Inhibitors/chemical synthesis; Receptors, Fibrinogen/antagonists & inhibitors; Thrombin/antagonists & inhibitors; Anticoagulants/chemistry; Anticoagulants/pharmacology; Benzoxazines/chemistry; Benzoxazines/pharmacology; Factor Xa Inhibitors; Fibrinogen/metabolism; Fibrinolytic Agents/chemistry; Fibrinolytic Agents/pharmacology; Models, Molecular; Molecular Mimicry; Molecular Weight; Oligopeptides/chemistry; Peptides/chemistry; Platelet Aggregation Inhibitors/chemistry; Platelet Aggregation Inhibitors/pharmacology; Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Platelet Aggregation Inhibitors / Thrombin / Receptors, Fibrinogen / Benzoxazines / Fibrinolytic Agents / Anticoagulants Type of study: Prognostic_studies Language: En Journal: J Med Chem Year: 2005 Document type: Article

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