Cyclooxygenase-2 expression in Warthin's tumour.
J Laryngol Otol
; 119(7): 515-8, 2005 Jul.
Article
in En
| MEDLINE
| ID: mdl-16175974
ABSTRACT
OBJECTIVES:
To determine whether cyclooxygenase-2 (COX-2) is overexpressed in Warthin's tumours, and to characterize its pattern of expression.METHODS:
Twenty-one paraffin-embedded Warthin's tumour specimens were analysed by immunohistochemical staining for expression of human COX-2. Semi-quantitative analysis of the staining was performed.RESULTS:
In all of the specimens, we found that there was overexpression of COX-2 within the epithelial component of the tumours, with no expression in the lymphoid components. There was also overexpression of COX-2 in the salivary duct system of normal parotid tissue.CONCLUSIONS:
Our results suggest that COX-2 is up-regulated in the epithelial component of Warthin's tumours. Our findings support the hypothesis that Warthin's tumours originate from heterotopic ductal epithelial cells of the parotid gland. The role of COX-2 expression in the pathogenesis of Warthin's tumours remains to be determined.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenolymphoma
/
Cyclooxygenase 2
Limits:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Laryngol Otol
Year:
2005
Document type:
Article