Differences in serum LH and FSH levels using depot or daily GnRH agonists in controlled ovarian stimulation: influence on ovarian response and outcome of ART.
J Assist Reprod Genet
; 22(7-8): 277-83, 2005 Aug.
Article
in En
| MEDLINE
| ID: mdl-16195824
ABSTRACT
PURPOSE:
To study effects of endogenous LH levels on ovarian response and outcome in ART cycles a controlled study was performed with two patient groups differing in the intensity of pituitary downregulation.METHODS:
Group I (n = 27) received 3.75 mg of the GnRH agonist triptorelin acetate depot, group II (n = 54) was given 0.1 mg triptorelin acetate daily, followed by ovarian stimulation with recombinant FSH.RESULTS:
After downregulation serum LH and FSH levels were significantly lower in group I. Patients of group I needed significantly higher FSH doses to achieve comparable levels of serum estradiol and preovulatory follicles. The number of retrieved oocytes and transferable embryos was lower in group I.CONCLUSION:
Patients with profound endogenous LH suppression by depot GnRH agonists show higher FSH stimulation dose requirements and lower oocyte number and fertilization rate, indicating a need for minimal LH activity in folliculogenesis and oocyte development.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovary
/
Ovulation Induction
/
Luteinizing Hormone
/
Gonadotropin-Releasing Hormone
/
Triptorelin Pamoate
/
Follicle Stimulating Hormone
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
J Assist Reprod Genet
Year:
2005
Document type:
Article