IKK{beta} as a target for treatment of inflammation induced bone loss.
Ann Rheum Dis
; 64 Suppl 4: iv81-5, 2005 Nov.
Article
in En
| MEDLINE
| ID: mdl-16239395
ABSTRACT
The transcription factor nuclear factor (NF)-kappaB is well recognised as a pivotal player in osteoclastogenesis and inflammation induced bone loss. Here, the authors discuss their recent results, obtained using a genetic approach in mice, that indicate the importance of IKKbeta, and not IKKalpha, as a transducer of signals from receptor activator of NF-kappaB (RANK) to NF-kappaB. Ablation of IKKbeta results in lack of osteoclastogenesis and unresponsiveness of IKKbeta deficient mice to inflammation induced bone loss. In the need of a more effective therapy for the treatment of inflammatory diseases causing bone resorption, specific inhibition of IKKbeta represents a logical alternative strategy to the current therapies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Resorption
/
I-kappa B Kinase
/
Inflammation
Limits:
Animals
/
Humans
Language:
En
Journal:
Ann Rheum Dis
Year:
2005
Document type:
Article