Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.

Nascimento, N R F; Lessa, L M A; Kerntopf, M R; Sousa, C M; Alves, R S; Queiroz, M G R; Price, J; Heimark, D B; Larner, J; Du, X; Brownlee, M; Gow, A; Davis, C; Fonteles, M C

Nascimento, N R F; Lessa, L M A; Kerntopf, M R; Sousa, C M; Alves, R S; Queiroz, M G R; Price, J; Heimark, D B; Larner, J; Du, X; Brownlee, M; Gow, A; Davis, C; Fonteles, M C.

Affiliation

Nascimento NR; College of Veterinary Medicine, State University of Ceará, Fortaleza, 60455-970 Ceará, Brazil.

Proc Natl Acad Sci U S A ; 103(1): 218-23, 2006 Jan 03.

Article in En | MEDLINE | ID: mdl-16373499

Subject(s)

Endothelium, Vascular/drug effects; Endothelium, Vascular/physiopathology; Hyperglycemia/drug therapy; Hypertriglyceridemia/drug therapy; Inositol Phosphates/pharmacology; Animals; Aorta/anatomy & histology; Aorta/metabolism; Enzyme Activation/drug effects; Inositol Phosphates/therapeutic use; Muscle Contraction/drug effects; Nitric Oxide/metabolism; Protein Kinase C/metabolism; Rabbits; Rats; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Hypertriglyceridemia / Hyperglycemia / Inositol Phosphates Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2006 Document type: Article

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