Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells.

Shacka, J J; Garner, M A; Gonzalez, J D; Ye, Y-Z; D'Alessandro, T L; Estévez, A G

Shacka, J J; Garner, M A; Gonzalez, J D; Ye, Y-Z; D'Alessandro, T L; Estévez, A G.

Affiliation

Shacka JJ; Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, USA.

Cell Death Differ ; 13(9): 1506-14, 2006 09.

Article in En | MEDLINE | ID: mdl-16410804

Subject(s)

Apoptosis; MAP Kinase Kinase 4/metabolism; Peroxynitrous Acid/physiology; Signal Transduction; p38 Mitogen-Activated Protein Kinases/metabolism; Animals; Caspases/metabolism; Cyclosporine/pharmacology; Cytochromes c/metabolism; Enzyme Activation; MAP Kinase Kinase 4/antagonists & inhibitors; MAP Kinase Kinase Kinases/antagonists & inhibitors; MAP Kinase Kinase Kinases/metabolism; Mitochondria/drug effects; Mitochondria/metabolism; Oncogene Protein v-akt/antagonists & inhibitors; Oncogene Protein v-akt/metabolism; PC12 Cells; Peroxynitrous Acid/pharmacology; Phosphorylation; Protein Kinase Inhibitors/pharmacology; Protein Transport; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; bcl-2-Associated X Protein/metabolism; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Apoptosis / Peroxynitrous Acid / MAP Kinase Kinase 4 / P38 Mitogen-Activated Protein Kinases Limits: Animals Language: En Journal: Cell Death Differ Year: 2006 Document type: Article

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