Design of novel bicyclic analogues derived from a potent oxytocin antagonist.

Flouret, George; Chaloin, Olivier; Borovickova, Lenka; Slaninová, Jirina

Flouret, George; Chaloin, Olivier; Borovickova, Lenka; Slaninová, Jirina.

Affiliation

Flouret G; Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611, USA. g-flouret@northwestern.edu

J Pept Sci ; 12(6): 412-9, 2006 Jun.

Article in En | MEDLINE | ID: mdl-16432806

Subject(s)

Hormone Antagonists/chemical synthesis; Oligopeptides/chemical synthesis; Oxytocin/antagonists & inhibitors; Peptides, Cyclic/chemical synthesis; Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Female; Hormone Antagonists/chemistry; Hormone Antagonists/pharmacology; Humans; In Vitro Techniques; Molecular Structure; Oligopeptides/chemistry; Oligopeptides/pharmacology; Oxytocin/chemistry; Oxytocin/pharmacology; Peptides, Cyclic/chemistry; Peptides, Cyclic/pharmacology; Rats; Receptors, Oxytocin/agonists; Receptors, Oxytocin/genetics; Structure-Activity Relationship; Uterine Contraction/drug effects; Uterus/drug effects; Uterus/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Peptides, Cyclic / Oxytocin / Hormone Antagonists Limits: Animals / Female / Humans Language: En Journal: J Pept Sci Year: 2006 Document type: Article

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