Endostatin therapy reveals a U-shaped curve for antitumor activity.

Tjin Tham Sjin, R M; Naspinski, J; Birsner, A E; Li, C; Chan, R; Lo, K-M; Gillies, S; Zurakowski, D; Folkman, J; Samulski, J; Javaherian, K

Tjin Tham Sjin, R M; Naspinski, J; Birsner, A E; Li, C; Chan, R; Lo, K-M; Gillies, S; Zurakowski, D; Folkman, J; Samulski, J; Javaherian, K.

Affiliation

Tjin Tham Sjin RM; Vascular Biology Program, Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

Cancer Gene Ther ; 13(6): 619-27, 2006 Jun.

Article in En | MEDLINE | ID: mdl-16456550

Subject(s)

Antineoplastic Agents/therapeutic use; Dependovirus/genetics; Endostatins/therapeutic use; Genetic Therapy/methods; Neoplasms/drug therapy; Amino Acid Sequence; Angiogenesis Inhibitors/administration & dosage; Angiogenesis Inhibitors/therapeutic use; Animals; Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal/genetics; Antibodies, Monoclonal/therapeutic use; Antineoplastic Agents/administration & dosage; Cell Line, Tumor; Cell Proliferation/drug effects; Dogs; Dose-Response Relationship, Drug; Endostatins/administration & dosage; Endostatins/genetics; Genetic Vectors; Humans; Injections, Intramuscular; Male; Mice; Mice, SCID; Molecular Sequence Data; Pancreatic Neoplasms/drug therapy; Sequence Alignment

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Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Dependovirus / Endostatins / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Cancer Gene Ther Year: 2006 Document type: Article

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