Immunohistochemical localization of glutamate in the gerbil main olfactory bulb using an antiserum directed against glutamate.
Anat Histol Embryol
; 35(2): 93-6, 2006 Apr.
Article
in En
| MEDLINE
| ID: mdl-16542173
ABSTRACT
Information on the localization and the roles of glutamate in the nervous system is becoming valuable because the axon terminals of the olfactory sensory neurons and the synapses of the mitral and tufted output cells appear to be glutamatergic. In this study, we have analysed the distribution of glutamate immunoreactivity in the main olfactory bulb (MOB) of the Mongolian gerbil using an antiserum directed against glutamate. Glutamate immunoreactivity in the MOB was present in the olfactory nerve layer (Onl), glomerular layer (GL), external plexiform layer (EPL) and mitral cell layer (ML), but not in the granule cell layer (GCL). Glutamate immunoreactivity detected in the Onl was thought to be terminal ramifications of glomeruli. Some neurons in the periglomerular region showed glutamate immunoreactivity. In the EPL, glutamate immunoreactivity was found in some neuronal somata (tufted cells) and processes. In addition, mitral cells in the ML were labelled by the glutamate antibody. The pattern of glutamate immunoreactivity in the mitral cells was similar to that in the tufted cells. In brief, glutamate in the gerbil MOB is the neurotransmitter used by primary afferents and output neurons.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Olfactory Bulb
/
Glutamic Acid
/
Neurons
Limits:
Animals
Language:
En
Journal:
Anat Histol Embryol
Year:
2006
Document type:
Article