Validation studies on the 5-hydroxy-L-[beta-11C]-tryptophan/PET method for probing the decarboxylase step in serotonin synthesis.

Lundquist, Pinelopi; Blomquist, Gunnar; Hartvig, Per; Hagberg, Gisela E; Torstenson, Richard; Hammarlund-Udenaes, Margareta; Långström, Bengt

Lundquist, Pinelopi; Blomquist, Gunnar; Hartvig, Per; Hagberg, Gisela E; Torstenson, Richard; Hammarlund-Udenaes, Margareta; Långström, Bengt.

Affiliation

Lundquist P; Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences,Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.

Synapse ; 59(8): 521-31, 2006 Jun 15.

Article in En | MEDLINE | ID: mdl-16565973

Subject(s)

5-Hydroxytryptophan/metabolism; Aromatic-L-Amino-Acid Decarboxylases/metabolism; Brain/metabolism; Carbon Radioisotopes/metabolism; Serotonin/biosynthesis; 5-Hydroxytryptophan/blood; 5-Hydroxytryptophan/pharmacokinetics; Animals; Aromatic-L-Amino-Acid Decarboxylases/drug effects; Brain/diagnostic imaging; Carbon Radioisotopes/blood; Carbon Radioisotopes/pharmacokinetics; Clorgyline/pharmacology; Enzyme Inhibitors/pharmacology; Female; Hydrazines/pharmacology; Macaca mulatta; Positron-Emission Tomography

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Collection: 01-internacional Database: MEDLINE Main subject: Aromatic-L-Amino-Acid Decarboxylases / Brain / Carbon Radioisotopes / Serotonin / 5-Hydroxytryptophan Limits: Animals Language: En Journal: Synapse Year: 2006 Document type: Article

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