Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice.
J Hepatol
; 13(2): 227-39, 1991 Sep.
Article
in En
| MEDLINE
| ID: mdl-1660504
ABSTRACT
A precise targeting of the SV40 T early region expression in the liver of transgenic mice was obtained using 700 bp of the antithrombin III regulatory sequences to control oncogene expression. In the strain expressing the highest level of large T antigen (Tag), the incidence of hepatocarcinoma was 100%. The evolution was reproducible and characterized by a marked cytolysis occurring as early as 4 weeks, when no morphological and histological modifications were visible, a preneoplastic state marked by a progression from hyperplasia to proliferative nodules composed of highly differentiated cells exhibiting a high Tag expression, which elicited tumor formation in nude mice and could proliferate in vitro, and hepatocellular carcinoma associated, in 10% of the cases, with lung metastasis. These transgenic mice constituted a useful model for therapeutic assays and fundamental studies on carcinogenesis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Liver Neoplasms, Experimental
/
Lung Neoplasms
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Hepatol
Year:
1991
Document type:
Article