siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts.

Dunne, J; Cullmann, C; Ritter, M; Soria, N Martinez; Drescher, B; Debernardi, S; Skoulakis, S; Hartmann, O; Krause, M; Krauter, J; Neubauer, A; Young, B D; Heidenreich, O

Dunne, J; Cullmann, C; Ritter, M; Soria, N Martinez; Drescher, B; Debernardi, S; Skoulakis, S; Hartmann, O; Krause, M; Krauter, J; Neubauer, A; Young, B D; Heidenreich, O.

Affiliation

Dunne J; Cancer Research UK Medical Oncology Laboratory, Barts and the London School of Medicine, London, UK.

Oncogene ; 25(45): 6067-78, 2006 Oct 05.

Article in En | MEDLINE | ID: mdl-16652140

Subject(s)

Cell Differentiation/genetics; Cell Proliferation; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Core Binding Factor Alpha 2 Subunit/physiology; DNA-Binding Proteins/physiology; Gene Expression Regulation, Neoplastic/physiology; Leukemia, Myeloid/genetics; Proto-Oncogene Proteins/physiology; RNA, Small Interfering/physiology; Transcription Factors/physiology; Translocation, Genetic; Acute Disease; Base Sequence; Cell Line, Tumor; Core Binding Factor Alpha 2 Subunit/genetics; DNA Primers; DNA-Binding Proteins/genetics; Gene Expression Profiling; Humans; Leukemia, Myeloid/pathology; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins/genetics; RUNX1 Translocation Partner 1 Protein; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors/genetics

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Translocation, Genetic / Chromosomes, Human, Pair 8 / Chromosomes, Human, Pair 21 / Leukemia, Myeloid / Gene Expression Regulation, Neoplastic / Cell Differentiation / Proto-Oncogene Proteins / RNA, Small Interfering / Cell Proliferation Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans / Male / Middle aged Language: En Journal: Oncogene Year: 2006 Document type: Article

Search on Google

XML

PubMed Links