Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction.

Lindsey, Merry L; Escobar, G Patricia; Mukherjee, Rupak; Goshorn, Danielle K; Sheats, Nina J; Bruce, James A; Mains, I Matthew; Hendrick, Jennifer K; Hewett, Kenneth W; Gourdie, Robert G; Matrisian, Lynn M; Spinale, Francis G

Lindsey, Merry L; Escobar, G Patricia; Mukherjee, Rupak; Goshorn, Danielle K; Sheats, Nina J; Bruce, James A; Mains, I Matthew; Hendrick, Jennifer K; Hewett, Kenneth W; Gourdie, Robert G; Matrisian, Lynn M; Spinale, Francis G.

Affiliation

Lindsey ML; Cardiology Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, Mail Code 7872, San Antonio, TX 78229-3900, USA. lindseym@uthscsa.edu

Circulation ; 113(25): 2919-28, 2006 Jun 27.

Article in En | MEDLINE | ID: mdl-16769909

Subject(s)

Connexin 43/metabolism; Heart Conduction System/physiopathology; Matrix Metalloproteinase 7/physiology; Myocardial Infarction/mortality; Myocardial Infarction/physiopathology; Amino Acid Sequence; Animals; Cell Communication; Dose-Response Relationship, Drug; Electric Conductivity; Electrocardiography; Gap Junctions/chemistry; Gap Junctions/pathology; Gene Deletion; Heart Block/etiology; Heart Block/physiopathology; Immunohistochemistry; Macrophages/chemistry; Macrophages/cytology; Macrophages/pathology; Matrix Metalloproteinase 7/analysis; Matrix Metalloproteinase 7/genetics; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Myocardial Infarction/pathology; Myocardium/chemistry; Myocardium/pathology; Myocytes, Cardiac/chemistry; Myocytes, Cardiac/cytology; Myocytes, Cardiac/pathology; Protein Binding/drug effects; Recombinant Proteins/pharmacology; Survival Analysis; Ventricular Remodeling/physiology

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Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Connexin 43 / Matrix Metalloproteinase 7 / Heart Conduction System / Myocardial Infarction Type of study: Etiology_studies Limits: Animals Language: En Journal: Circulation Year: 2006 Document type: Article

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