Triterpenes from Tripterygium wilfordii Hook.

Yang, J-H; Luo, S-D; Wang, Y-S; Zhao, J-F; Zhang, H-B; Li, L

Yang, J-H; Luo, S-D; Wang, Y-S; Zhao, J-F; Zhang, H-B; Li, L.

Affiliation

Yang JH; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Graduate School of the Chinese Academy of Sciences, Kunming, Yunnan 650204, China.

J Asian Nat Prod Res ; 8(5): 425-9, 2006.

Article in En | MEDLINE | ID: mdl-16864458

ABSTRACT

ABSTRACT

Two new friedelane-type triterpenes, tripterfrielanons A (1) and B (2), along with six known triterpenoids, friedelin (3), canophyllal (4), canophyllalic acid (5), 3-oxo-29-hydroxyfriedelane (6), wilforlide A (7), wilforlide B (8), have been isolated from the EtOH extract of the roots of Tripterygiumwilfordii Hook.f. Compounds 4, 5, 6 were isolated for the first time from this plant. The new triterpenes 1 and 2 exhibited mild cytotoxic activity against human Hela cell lines in vitro. The assay showed the IC50 of 1 and 2 were 8.5 and 25 microg/mL, respectively.

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Phytotherapy; Plant Extracts/pharmacology; Tripterygium; Antineoplastic Agents, Phytogenic/administration & dosage; Antineoplastic Agents, Phytogenic/therapeutic use; HeLa Cells/drug effects; Humans; Inhibitory Concentration 50; Plant Extracts/administration & dosage; Plant Extracts/therapeutic use; Plant Roots; Triterpenes/administration & dosage; Triterpenes/pharmacology; Triterpenes/therapeutic use

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Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Tripterygium / Phytotherapy / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: J Asian Nat Prod Res Year: 2006 Document type: Article

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