Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.

Rahman, Shaila; Lu, Richard; Vandegraaff, Nick; Cherepanov, Peter; Engelman, Alan

Rahman, Shaila; Lu, Richard; Vandegraaff, Nick; Cherepanov, Peter; Engelman, Alan.

Affiliation

Rahman S; Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Virology ; 357(1): 79-90, 2007 Jan 05.

Article in En | MEDLINE | ID: mdl-16959283

Subject(s)

HIV Integrase/metabolism; HIV-1/physiology; Intercellular Signaling Peptides and Proteins/metabolism; Cell Line; HIV Infections/virology; HIV Integrase/chemistry; HIV Integrase/genetics; HIV-1/metabolism; HeLa Cells; Humans; Jurkat Cells; Models, Molecular; Mutagenesis; Protein Binding; Virus Integration

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Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / HIV Integrase / Intercellular Signaling Peptides and Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Virology Year: 2007 Document type: Article

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