[Significance of "anti HBC alone" serological profile in 284 patients suspicious of being infected with hepatitis B virus]. / Signification du profil sérologique "anticorps anti-HBC isolés" chez 284 patients suspects d'être infectés par le virus de l'hépatite B.
Ann Biol Clin (Paris)
; 64(5): 451-5, 2006.
Article
in Fr
| MEDLINE
| ID: mdl-17040876
ABSTRACT
The "anti-HBc alone" serological profile is a frequent finding in hepatitis B virus infections, but little is known about its clinical significance. The aim of this study was to explore the 'anti-HBc alone' serological profile obtained by immunosorbent assay (ELISA) in 284 patients suspicious of being infected with hepatitis B virus. Sera were screened for following serological markers HBs Ag, anti-HBc and anti-HBs antibodies using immunoradiometric assay (IRMA) and for HBV DNA using polymerase chain reaction. Among 284 studied sera with 'anti-HBc alone' serological profile, 124 were positives for anti-HBs antibodies by IRMA and corresponding to a recovered form of hepatitis B. Nineteen sera were negatives for anti-HBc antibodies, suggesting false positive results by ELISA. Two sera were found positives for HBs Ag by IRMA, which are related to authentic hepatitis B. HBV DNA was positive in 4 sera, suggesting occult hepatitis B. This study indicates that "anti-HBc alone" serological profile is most often correlates with recovered hepatitis B infection, but it can mask an occult hepatitis B.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatitis B virus
/
Hepatitis B
/
Hepatitis B Antibodies
Type of study:
Observational_studies
Limits:
Humans
Language:
Fr
Journal:
Ann Biol Clin (Paris)
Year:
2006
Document type:
Article