Toxicity of a trivalent organic arsenic compound, dimethylarsinous glutathione in a rat liver cell line (TRL 1215).

Sakurai, T; Kojima, C; Kobayashi, Y; Hirano, S; Sakurai, M H; Waalkes, M P; Himeno, S

Sakurai, T; Kojima, C; Kobayashi, Y; Hirano, S; Sakurai, M H; Waalkes, M P; Himeno, S.

Affiliation

Sakurai T; Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan. teruaki@ph.bunri-u.ac.jp

Br J Pharmacol ; 149(7): 888-97, 2006 Dec.

Article in En | MEDLINE | ID: mdl-17043674

Subject(s)

Cacodylic Acid/analogs & derivatives; Glutathione/analogs & derivatives; Glutathione/pharmacology; Hepatocytes/drug effects; Animals; Antineoplastic Agents/adverse effects; Antineoplastic Agents/metabolism; Arsenic Poisoning/metabolism; Arsenicals/chemical synthesis; Arsenicals/metabolism; Arsenites/adverse effects; Arsenites/metabolism; Cacodylic Acid/chemistry; Cacodylic Acid/metabolism; Cacodylic Acid/toxicity; Cell Line; Cell Survival/drug effects; Chromatography, Thin Layer/methods; Dose-Response Relationship, Drug; Erythrocytes; Glutathione/chemical synthesis; Glutathione/chemistry; Glutathione/metabolism; Glutathione/toxicity; Hepatocytes/metabolism; Humans; Inhibitory Concentration 50; Methylation; Rats; Rats, Inbred F344; Serum Albumin/metabolism; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cacodylic Acid / Hepatocytes / Glutathione Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 2006 Document type: Article

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