Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model.

Jacqmin, P; Snoeck, E; van Schaick, E A; Gieschke, R; Pillai, P; Steimer, J-L; Girard, P

Jacqmin, P; Snoeck, E; van Schaick, E A; Gieschke, R; Pillai, P; Steimer, J-L; Girard, P.

Affiliation

Jacqmin P; Exprimo NV, Berenlaan, 4, Beerse, B-2340, Belgium. philippe.jacqmin@exprimo.com

J Pharmacokinet Pharmacodyn ; 34(1): 57-85, 2007 Feb.

Article in En | MEDLINE | ID: mdl-17051439

Subject(s)

Adenosine A1 Receptor Agonists; Adenosine/analogs & derivatives; Lipolysis/drug effects; Models, Biological; Models, Statistical; Adenosine/administration & dosage; Adenosine/pharmacokinetics; Animals; Computer Simulation; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Male; Rats; Rats, Wistar; Reproducibility of Results; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Adenosine / Models, Statistical / Adenosine A1 Receptor Agonists / Lipolysis / Models, Biological Type of study: Evaluation_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: J Pharmacokinet Pharmacodyn Year: 2007 Document type: Article

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