Activatory properties of lysophosphatidic acid on human THP-1 cells.
Inflammation
; 29(4-6): 129-40, 2005 Dec.
Article
in En
| MEDLINE
| ID: mdl-17089191
ABSTRACT
Excessive leukocyte proliferation and proinflammatory mediators release represent common phenomena in several chronic inflammatory diseases. Multiple evidences identify lysophosphatidic acid (LPA), a small lipid endowed with pleiotropic activities, as an important modulator of both proliferation and activation of different cell types involved in several inflammation-associated pathologies. However, its possible role on monocyte proinflammatory activation is not fully understood yet. Aim of the present study was to investigate LPA effects on THP-1 cells in terms of proliferation, reactive oxygen intermediates (ROI) production and release of arachidonic acid-derived inflammatory mediators. Actually, LPA significantly increased both DNA synthesis and ROI production as well as prostaglandin E(2) release and the upregulation of LPA(3) receptor expression. These findings identified LPA as both a growth factor and a triggering mediator of proinflammatory response in THP-1 cells.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lysophospholipids
/
Monocytes
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Inflammation
Year:
2005
Document type:
Article