ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients.

Takatori, R; Takahashi, K A; Tokunaga, D; Hojo, T; Fujioka, M; Asano, T; Hirata, T; Kawahito, Y; Satomi, Y; Nishino, H; Tanaka, T; Hirota, Y; Kubo, T

Takatori, R; Takahashi, K A; Tokunaga, D; Hojo, T; Fujioka, M; Asano, T; Hirata, T; Kawahito, Y; Satomi, Y; Nishino, H; Tanaka, T; Hirota, Y; Kubo, T.

Affiliation

Takatori R; Dept. of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. r-taka@koto.kpu-m.ac.jp

Clin Exp Rheumatol ; 24(5): 546-54, 2006.

Article in En | MEDLINE | ID: mdl-17181924

Subject(s)

Antirheumatic Agents/therapeutic use; Arthritis, Rheumatoid/drug therapy; Drug Resistance, Multiple/genetics; Methotrexate/therapeutic use; Organic Anion Transporters/genetics; Polymorphism, Genetic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Antirheumatic Agents/adverse effects; Arthritis, Rheumatoid/genetics; Arthritis, Rheumatoid/physiopathology; Female; Genotype; Health Status; Humans; Hydroxymethyl and Formyl Transferases/genetics; Joints/physiopathology; Male; Membrane Transport Proteins/genetics; Methotrexate/adverse effects; Middle Aged; Multienzyme Complexes/genetics; Nucleotide Deaminases/genetics; Retrospective Studies; Severity of Illness Index; Thymidylate Synthase/genetics; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Arthritis, Rheumatoid / Methotrexate / Drug Resistance, Multiple / Antirheumatic Agents / Organic Anion Transporters Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Patient_preference Limits: Female / Humans / Male / Middle aged Language: En Journal: Clin Exp Rheumatol Year: 2006 Document type: Article

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