Novel immunosuppressant agents targeting activated lymphocytes by biocompatible MPC polymer conjugated with interleukin-2.

Chiba, N; Ueda, M; Shimada, T; Jinno, H; Watanabe, J; Ishihara, K; Kitajima, M

Chiba, N; Ueda, M; Shimada, T; Jinno, H; Watanabe, J; Ishihara, K; Kitajima, M.

Affiliation

Chiba N; Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Eur Surg Res ; 39(2): 103-10, 2007.

Article in En | MEDLINE | ID: mdl-17299267

Subject(s)

Cyclosporine/pharmacokinetics; Immunosuppressive Agents/pharmacokinetics; Interleukin-2/pharmacokinetics; Lymphocyte Activation/drug effects; Methacrylates/pharmacokinetics; Polyethylene Glycols/pharmacokinetics; T-Lymphocytes/drug effects; Antineoplastic Agents, Phytogenic/pharmacokinetics; Biocompatible Materials/chemical synthesis; Biocompatible Materials/pharmacokinetics; Cell Division/drug effects; Cell Line, Tumor; Drug Delivery Systems/methods; Humans; Hydrophobic and Hydrophilic Interactions; Interleukin-2/chemical synthesis; Lymphocyte Culture Test, Mixed; Methacrylates/chemical synthesis; Paclitaxel/pharmacokinetics; Polyethylene Glycols/chemical synthesis; Solubility; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Tacrolimus/pharmacokinetics

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Lymphocyte Activation / T-Lymphocytes / Interleukin-2 / Cyclosporine / Immunosuppressive Agents / Methacrylates Limits: Humans Language: En Journal: Eur Surg Res Year: 2007 Document type: Article

Search on Google

XML

PubMed Links