Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.

Yang, Zhiyong; Venardos, Kylie; Jones, Emma; Morris, Brian J; Chin-Dusting, Jaye; Kaye, David M

Yang, Zhiyong; Venardos, Kylie; Jones, Emma; Morris, Brian J; Chin-Dusting, Jaye; Kaye, David M.

Affiliation

Yang Z; Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia.

Circulation ; 115(10): 1269-74, 2007 Mar 13.

Article in En | MEDLINE | ID: mdl-17325243

Subject(s)

3' Flanking Region/genetics; Cationic Amino Acid Transporter 1/genetics; Endothelial Cells/metabolism; Hypertension/genetics; Polymorphism, Genetic; Animals; Aorta/drug effects; Aorta/physiopathology; Arginine/metabolism; CHO Cells; Cells, Cultured; Cricetinae; Cricetulus; Electrophoretic Mobility Shift Assay; Gene Frequency; Gene Transfer Techniques; Genes, Reporter; Genotype; HeLa Cells; Humans; Mice; Nitric Oxide; Organ Culture Techniques; Vasodilation/drug effects; Vasodilation/genetics; Vasodilator Agents/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Cationic Amino Acid Transporter 1 / 3' Flanking Region / Endothelial Cells / Hypertension Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Circulation Year: 2007 Document type: Article

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