Synthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier-Haack reaction.
Eur J Med Chem
; 42(8): 1128-36, 2007 Aug.
Article
in En
| MEDLINE
| ID: mdl-17331623
The study of the Vilsmeier-Haack reagent on 4-hydroxyquinaldines resulted in a new versatile intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-1-yl)quinolines, which on further treatment with hydrazine hydrate yielded the desired diazepino quinoline derivatives. All the synthesized diazepino quinoline derivatives are screened for their antibacterial and antifungal activities. Cytogenetic analysis of the samples is also reported.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolines
/
Azepines
/
Chromosome Aberrations
/
Anti-Infective Agents
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Eur J Med Chem
Year:
2007
Document type:
Article