An efficient and safe herpes simplex virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas.

Lam, Paula Y P; Sia, Kian Chuan; Khong, Jenn H; De Geest, Bart; Lim, Kar S; Ho, Ivy A W; Wang, Grace Y; Miao, L V; Huynh, H; Hui, Kam M

Lam, Paula Y P; Sia, Kian Chuan; Khong, Jenn H; De Geest, Bart; Lim, Kar S; Ho, Ivy A W; Wang, Grace Y; Miao, L V; Huynh, H; Hui, Kam M.

Affiliation

Lam PY; Laboratory of Cancer Gene Therapy, Division of Cellular and Molecular Research, National Cancer Centre, Singapore. cmrlyp@nccs.com.sg

Mol Ther ; 15(6): 1129-36, 2007 Jun.

Article in En | MEDLINE | ID: mdl-17426711

Subject(s)

Carcinoma, Hepatocellular/therapy; Genetic Therapy/methods; Herpesvirus 1, Human/genetics; Liver Neoplasms/therapy; Transcription, Genetic/genetics; Animals; Apolipoproteins E/genetics; CCAAT-Binding Factor/genetics; Carcinoma, Hepatocellular/genetics; Carcinoma, Hepatocellular/pathology; Cell Line; Cell Line, Tumor; Female; Gene Amplification; Genetic Vectors/genetics; HeLa Cells; Humans; Immunoblotting; Liver Neoplasms/genetics; Liver Neoplasms/pathology; Luciferases/genetics; Luciferases/metabolism; Mice; Mice, Inbred BALB C; Mice, SCID; Microscopy, Fluorescence; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Xenograft Model Antitumor Assays/methods; alpha 1-Antitrypsin/genetics; alpha-Fetoproteins/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Genetic Therapy / Herpesvirus 1, Human / Carcinoma, Hepatocellular / Liver Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Mol Ther Year: 2007 Document type: Article

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