Development of a drug delivery device: using the femtosecond laser to modify cochlear implant electrodes.
Cochlear Implants Int
; 8(1): 38-52, 2007 Mar.
Article
in En
| MEDLINE
| ID: mdl-17479965
ABSTRACT
Animal experiments suggest that pharmacological intervention could possibly enhance cochlear implant performance. One of the key aspects is therefore a drug delivery device for the human inner ear. The objective of this study was to investigate the possibility of using the femtosecond laser for modifying a cochlear implant electrode for the purpose of drug delivery to the cochlea. Using silicone sheets, the best parameters for creating defined channels at calculated diameters were investigated using a femtosecond laser. The results were transferred to a cochlear implant electrode array (Nucleus Contour). The capability of delivering substances through the drilled openings was tested in vitro. By variation of the output of the laser, spot distance, repetition rate, number of cycles and introducing several focus planes, it was possible to drill holes with nearly vertical walls in the silicone sheets. Transferring these data to the cochlear implant electrode resulted in prototypes for drug delivery with various openings along the array. The use of the femtosecond laser allows rapid modification and adaptation of designs to experimental prototypes of cochlear implant electrodes for the purpose of drug delivery to the inner ear.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cochlear Implants
/
Drug Delivery Systems
/
Cochlea
/
Lasers
Aspects:
Implementation_research
Limits:
Humans
Language:
En
Journal:
Cochlear Implants Int
Year:
2007
Document type:
Article