Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.

Armstrong, J L; Taylor, G A; Thomas, H D; Boddy, A V; Redfern, C P F; Veal, G J

Armstrong, J L; Taylor, G A; Thomas, H D; Boddy, A V; Redfern, C P F; Veal, G J.

Affiliation

Armstrong JL; Newcastle University, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.

Br J Cancer ; 96(11): 1675-83, 2007 Jun 04.

Article in En | MEDLINE | ID: mdl-17486130

Subject(s)

Benzothiazoles/pharmacology; Cytochrome P-450 Enzyme Inhibitors; Imidazoles/pharmacology; Neuroblastoma/metabolism; Tretinoin/metabolism; Animals; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Female; Humans; Isoenzymes/metabolism; Mice; Mice, Nude; Neuroblastoma/pathology; RNA, Small Interfering/pharmacology; Retinoic Acid 4-Hydroxylase; Transplantation, Heterologous; Tretinoin/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tretinoin / Benzothiazoles / Cytochrome P-450 Enzyme Inhibitors / Imidazoles / Neuroblastoma Limits: Animals / Female / Humans Language: En Journal: Br J Cancer Year: 2007 Document type: Article

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