Aqueous peroxyl radical exposure to THP-1 cells causes glutathione loss followed by protein oxidation and cell death without increased caspase-3 activity.

Kappler, Marion; Gerry, Andrew B; Brown, Erin; Reid, Linzi; Leake, David S; Gieseg, Steven P

Kappler, Marion; Gerry, Andrew B; Brown, Erin; Reid, Linzi; Leake, David S; Gieseg, Steven P.

Affiliation

Kappler M; Free Radical Biochemistry Laboratory, School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.

Biochim Biophys Acta ; 1773(6): 945-53, 2007 Jun.

Article in En | MEDLINE | ID: mdl-17509699

Subject(s)

Caspase 3/metabolism; Glutathione/metabolism; Peroxides/pharmacology; Amidines/pharmacology; Annexin A5/metabolism; Cell Line; Enzyme Activation/drug effects; Humans; Hydroxyl Radical/metabolism; Hydroxyl Radical/pharmacology; Necrosis/enzymology; Necrosis/pathology; Oxidants/pharmacology; Oxidation-Reduction/drug effects; Peroxides/metabolism; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Peroxides / Caspase 3 / Glutathione Type of study: Etiology_studies Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2007 Document type: Article

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