Transdermal and buccal delivery of methylxanthines through human tissue in vitro.
Drug Dev Ind Pharm
; 33(5): 513-21, 2007 May.
Article
in En
| MEDLINE
| ID: mdl-17520442
ABSTRACT
We examined the in vitro permeation of central nervous stimulants - caffeine, theophylline, and theobromine across human skin with the aid of six chemical enhancers. It was found that oleic acid was the most potent enhancer for all three methylxanthines. Further optimization studies with different solvents showed that caffeine transport could be enhanced to give flux values up to 585 microg/cm2.hr-1. Theobromine and theophylline delivery rates proved insufficient. An additional study involving a buccal tissue equivalent showed that this membrane was more permeable than skin for all model actives tested and would offer an alternate way of delivery.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Theobromine
/
Theophylline
/
Xanthenes
/
Caffeine
/
Excipients
/
Central Nervous System Stimulants
Limits:
Humans
Language:
En
Journal:
Drug Dev Ind Pharm
Year:
2007
Document type:
Article