Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors.

Simoncini, T; Fu, X-D; Caruso, A; Garibaldi, S; Baldacci, C; Giretti, M S; Mannella, P; Flamini, M I; Sanchez, A M; Genazzani, A R

Simoncini, T; Fu, X-D; Caruso, A; Garibaldi, S; Baldacci, C; Giretti, M S; Mannella, P; Flamini, M I; Sanchez, A M; Genazzani, A R.

Affiliation

Simoncini T; Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 57, Pisa 56100, Italy. t.simoncini@obgyn.med.unipi.it

Hum Reprod ; 22(8): 2325-34, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17545686

Subject(s)

Androstenes/pharmacology; Nitric Oxide Synthase Type III/metabolism; Receptors, Mineralocorticoid/drug effects; Receptors, Progesterone/drug effects; Aldosterone/pharmacology; Androstadienes/pharmacology; Cells, Cultured; Endothelium, Vascular/cytology; Enzyme Activation; Estradiol/pharmacology; Flavonoids/pharmacology; Humans; Medroxyprogesterone Acetate/pharmacology; Mifepristone/pharmacology; Nitric Oxide/biosynthesis; Nitric Oxide Synthase Type III/drug effects; Progesterone/pharmacology; Signal Transduction/drug effects; Time Factors; Wortmannin

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Progesterone / Receptors, Mineralocorticoid / Nitric Oxide Synthase Type III / Androstenes Limits: Humans Language: En Journal: Hum Reprod Year: 2007 Document type: Article

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