BM-520, an original TXA2 modulator, inhibits the action of thromboxane A2 and 8-iso-prostaglandin F2alphain vitro and in vivo on human and rodent platelets, and aortic vascular smooth muscles from rodents.

Rolin, S; Hanson, J; Vastersaegher, C; Cherdon, C; Pratico, D; Masereel, B; Dogne, J M

Rolin, S; Hanson, J; Vastersaegher, C; Cherdon, C; Pratico, D; Masereel, B; Dogne, J M.

Affiliation

Rolin S; Department of Pharmacy, University of Namur, Rue de Bruxelles, 61, B-5000 Namur, Belgium.

Prostaglandins Other Lipid Mediat ; 84(1-2): 14-23, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17643884

Subject(s)

Aorta/metabolism; Dinoprost/analogs & derivatives; Diphenylamine/analogs & derivatives; Muscle, Smooth, Vascular/metabolism; Sulfonylurea Compounds/chemistry; Thromboxane A2/metabolism; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/chemistry; Animals; Aorta/drug effects; Blood Platelets/metabolism; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost/chemistry; Diphenylamine/chemistry; Diphenylamine/pharmacology; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines/chemistry; Male; Models, Chemical; Rats; Rats, Wistar; Sulfonylurea Compounds/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Sulfonylurea Compounds / Thromboxane A2 / Dinoprost / Diphenylamine / Muscle, Smooth, Vascular Limits: Animals / Humans / Male Language: En Journal: Prostaglandins Other Lipid Mediat Year: 2007 Document type: Article

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