Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax.

Albrecht, Mark T; Li, Han; Williamson, E Diane; LeButt, Chris S; Flick-Smith, Helen C; Quinn, Conrad P; Westra, Hans; Galloway, Darrell; Mateczun, Alfred; Goldman, Stanley; Groen, Herman; Baillie, Les W J

Albrecht, Mark T; Li, Han; Williamson, E Diane; LeButt, Chris S; Flick-Smith, Helen C; Quinn, Conrad P; Westra, Hans; Galloway, Darrell; Mateczun, Alfred; Goldman, Stanley; Groen, Herman; Baillie, Les W J.

Affiliation

Albrecht MT; Biological Defense Research Directorate, Naval Medical Research Center, 12300 Washington Ave., Silver Spring, MD 20910-7500, USA. albrechtm@nmrc.navy.mil

Infect Immun ; 75(11): 5425-33, 2007 Nov.

Article in En | MEDLINE | ID: mdl-17646360

Subject(s)

Anthrax/drug therapy; Anthrax/prevention & control; Antibodies, Monoclonal/immunology; Antigens, Bacterial/immunology; Antitoxins/pharmacology; Bacillus anthracis/immunology; Bacterial Toxins/immunology; Animals; Anthrax/immunology; Antibodies, Bacterial/blood; Female; Humans; Hybridomas; Immunization, Passive; Immunoglobulin G/blood; Inhibitory Concentration 50; Mice; Survival Analysis

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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Bacillus anthracis / Bacterial Toxins / Antitoxins / Anthrax / Antibodies, Monoclonal / Antigens, Bacterial Limits: Animals / Female / Humans Language: En Journal: Infect Immun Year: 2007 Document type: Article

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