Comparison of nilotinib and imatinib inhibition of FMS receptor signaling, macrophage production and osteoclastogenesis.

Brownlow, N; Russell, A E; Saravanapavan, H; Wiesmann, M; Murray, J M; Manley, P W; Dibb, N J

Brownlow, N; Russell, A E; Saravanapavan, H; Wiesmann, M; Murray, J M; Manley, P W; Dibb, N J.

Leukemia ; 22(3): 649-52, 2008 Mar.

Article in En | MEDLINE | ID: mdl-17851554

Subject(s)

Genes, fms; Macrophages/drug effects; Osteoclasts/drug effects; Piperazines/pharmacology; Protein Kinase Inhibitors/pharmacology; Pyrimidines/pharmacology; Receptor, Macrophage Colony-Stimulating Factor/antagonists & inhibitors; Amino Acid Substitution; Animals; Apoptosis/drug effects; Benzamides; Cell Differentiation/drug effects; Cells, Cultured/drug effects; Drug Evaluation, Preclinical; Drug Resistance/genetics; Fibroblasts/drug effects; Fibroblasts/enzymology; Humans; Imatinib Mesylate; Macrophage Colony-Stimulating Factor/pharmacology; Macrophages/cytology; Mesenchymal Stem Cells/cytology; Mesenchymal Stem Cells/drug effects; Mice; Mutation, Missense; Osteoclasts/cytology; Osteoclasts/physiology; Phosphorylation/drug effects; Point Mutation; Protein Processing, Post-Translational/drug effects; Rats; Signal Transduction/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Piperazines / Pyrimidines / Genes, fms / Receptor, Macrophage Colony-Stimulating Factor / Protein Kinase Inhibitors / Macrophages Limits: Animals / Humans Language: En Journal: Leukemia Year: 2008 Document type: Article

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