New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes.

Xu, Lan-Lan; Zou, Kun; Wang, Jun-Zhi; Wu, Jun; Zhou, Yuan; Dan, Fei-Jun; Yang, Jing

Xu, Lan-Lan; Zou, Kun; Wang, Jun-Zhi; Wu, Jun; Zhou, Yuan; Dan, Fei-Jun; Yang, Jing.

Affiliation

Xu LL; Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, PR China. llxu@ctgu.edu.cn

Molecules ; 12(8): 2029-37, 2007 Aug 23.

Article in En | MEDLINE | ID: mdl-17960103

ABSTRACT

ABSTRACT

Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 microg/mL.

Subject(s)

Nitric Oxide/antagonists & inhibitors; Rhizome/chemistry; Saponins/chemistry; Saponins/pharmacology; Animals; Lipopolysaccharides/pharmacology; Macrophages/drug effects; Macrophages/metabolism; Nitric Oxide/biosynthesis; Rats; Saponins/isolation & purification

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saponins / Rhizome / Nitric Oxide Limits: Animals Language: En Journal: Molecules Year: 2007 Document type: Article

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