Structure-based drug design of a novel family of chalcones as PPARalpha agonists: virtual screening, synthesis, and biological activities in vitro.

Li, Xiang-hua; Zou, Han-jun; Wu, An-hui; Ye, Yang-liang; Shen, Jian-hua

Li, Xiang-hua; Zou, Han-jun; Wu, An-hui; Ye, Yang-liang; Shen, Jian-hua.

Affiliation

Li XH; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Acta Pharmacol Sin ; 28(12): 2040-52, 2007 Dec.

Article in En | MEDLINE | ID: mdl-18031621

Subject(s)

Chalcones/chemistry; Chalcones/pharmacology; Drug Design; PPAR alpha/agonists; Magnetic Resonance Spectroscopy; Models, Molecular; Spectrometry, Mass, Electrospray Ionization

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Chalcones / PPAR alpha Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Acta Pharmacol Sin Year: 2007 Document type: Article

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