Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance.

Kline, T; Trent, M S; Stead, C M; Lee, M S; Sousa, M C; Felise, H B; Nguyen, H V; Miller, S I

Kline, T; Trent, M S; Stead, C M; Lee, M S; Sousa, M C; Felise, H B; Nguyen, H V; Miller, S I.

Affiliation

Kline T; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Bioorg Med Chem Lett ; 18(4): 1507-10, 2008 Feb 15.

Article in En | MEDLINE | ID: mdl-18187325

Subject(s)

Anti-Bacterial Agents/pharmacology; Arabinose/analogs & derivatives; Lipid A/metabolism; Polymyxins/pharmacology; Arabinose/chemical synthesis; Arabinose/pharmacology; Azides/chemical synthesis; Azides/pharmacology; Drug Resistance, Microbial; Drug Synergism; Hexosyltransferases/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arabinose / Polymyxins / Lipid A / Anti-Bacterial Agents Language: En Journal: Bioorg Med Chem Lett Year: 2008 Document type: Article

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