Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells.

Yoo, Y-G; Na, T-Y; Seo, H-W; Seong, J K; Park, C K; Shin, Y K; Lee, M-O

Yoo, Y-G; Na, T-Y; Seo, H-W; Seong, J K; Park, C K; Shin, Y K; Lee, M-O.

Affiliation

Yoo YG; College of Pharmacy, Seoul National University, Seoul, Korea.

Oncogene ; 27(24): 3405-13, 2008 May 29.

Article in En | MEDLINE | ID: mdl-18264140

Subject(s)

Carcinoma, Hepatocellular/metabolism; Cell Hypoxia; Histone Deacetylases/genetics; Repressor Proteins/genetics; Trans-Activators/physiology; Transcription Factors/genetics; Acetylation; Animals; Blotting, Western; Carcinoma, Hepatocellular/pathology; Carcinoma, Hepatocellular/virology; Gene Expression; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylases/metabolism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Immunoenzyme Techniques; Immunoprecipitation; Liver/metabolism; Liver Neoplasms/metabolism; Liver Neoplasms/pathology; Liver Neoplasms/virology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Repressor Proteins/metabolism; Retrospective Studies; Signal Transduction; Transcription Factors/metabolism; Tumor Cells, Cultured; Viral Regulatory and Accessory Proteins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Transcription Factors / Cell Hypoxia / Trans-Activators / Carcinoma, Hepatocellular / Histone Deacetylases Type of study: Observational_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Oncogene Year: 2008 Document type: Article

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