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CD44 is highly expressed on milk neutrophils in bovine mastitis and plays a role in their adhesion to matrix and mammary epithelium.
Gonen, Erez; Nedvetzki, Shlomo; Naor, David; Shpigel, Nahum Y.
Affiliation
  • Gonen E; The Koret School of Veterinary Medicine, Faculty of Agriculture, POB 12, Rehovot 76100, Israel.
Vet Res ; 39(3): 29, 2008.
Article in En | MEDLINE | ID: mdl-18275804
Mastitis, inflammation of the mammary gland, is a common and economically important disease in dairy animals. Mammary pathogenic organisms, such as Escherichia coli, invade the teat canal,milk ducts, and mammary alveolar space, replicate in mammary secretions, and elicit a local inflammatory response characterized by massive recruitment of blood polymorphonuclear neutrophil leukocytes (PMN) into the alveoli and milk ducts. CD44 is a trans-membrane glycoprotein previously shown to play a role in mediation and control of blood PMN recruitment in response to inflammatory signals. Here we show, for the first time, increased expression of CD44 on recruited milk PMN in bovine mastitis and the expression of a CD44 variant, CD44v10, on these PMN. Furthermore, we demonstrate that CD44 mediates specific adhesion of bovine blood PMN to hyaluronic acid and mammary epithelial cells. Our results suggest that in mastitis CD44 plays a role in recruiting blood PMN into the mammary glands, the exact nature of this role needs to be elucidated.
Subject(s)

Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Hyaluronan Receptors / Milk / Mastitis, Bovine / Neutrophils Limits: Animals Language: En Journal: Vet Res Year: 2008 Document type: Article

Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Hyaluronan Receptors / Milk / Mastitis, Bovine / Neutrophils Limits: Animals Language: En Journal: Vet Res Year: 2008 Document type: Article