Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication.
Arch Neurol
; 65(4): 540-4, 2008 Apr.
Article
in En
| MEDLINE
| ID: mdl-18413480
OBJECTIVE: To investigate amyloid accumulation by carbon 11-labeled Pittsburgh Compound B (11C-PiB) in hereditary cerebral amyloid angiopathy and APP locus duplication. DESIGN, SETTING, AND PATIENTS: Positron emission tomography with 11C-PiB and magnetic resonance imaging were performed for 2 patients, 49-year-old and 60-year-old siblings with APP locus duplication, with hereditary Alzheimer disease and cerebral amyloid angiopathy. MAIN OUTCOME MEASURE: Change in 11C-PiB uptake. RESULTS: Uptake of 11C-PiB was increased especially in the striatum (caudate nucleus to 225% and 280% of the control mean and putamen to 166% and 185% of the control mean) and in the posterior cingulate (to 168% and 198% of the control mean), and it was marginally increased in other cortical brain areas. The pattern of increased 11C-PiB uptake was different from that seen in sporadic Alzheimer disease. CONCLUSIONS: Amyloid imaging with 11C-PiB positron emission tomography is a useful tool for detecting in vivo amyloid accumulation in patients with hereditary cerebral amyloid angiopathy. However, the pattern of 11C-PiB accumulation differs between patients with typical AD and patients with APP locus duplication.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thiazoles
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Image Processing, Computer-Assisted
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Brain
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Carbon Radioisotopes
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Magnetic Resonance Imaging
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Amyloid beta-Protein Precursor
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Receptors, Cell Surface
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Cerebral Amyloid Angiopathy, Familial
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Positron-Emission Tomography
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Alzheimer Disease
Type of study:
Diagnostic_studies
Limits:
Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Arch Neurol
Year:
2008
Document type:
Article