Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease.

Oyagi, A; Oida, Y; Hara, H; Izuta, H; Shimazawa, M; Matsunaga, N; Adachi, T; Hara, H

Oyagi, A; Oida, Y; Hara, H; Izuta, H; Shimazawa, M; Matsunaga, N; Adachi, T; Hara, H.

Affiliation

Oyagi A; Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.

Brain Res ; 1214: 169-76, 2008 Jun 12.

Article in En | MEDLINE | ID: mdl-18457816

Subject(s)

Aniline Compounds/therapeutic use; Antioxidants/therapeutic use; Parkinsonian Disorders/prevention & control; Piperazines/therapeutic use; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic Agents/toxicity; Analysis of Variance; Animals; Body Weight/drug effects; Body Weight/physiology; Cell Death/drug effects; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydrogen Peroxide/pharmacology; Lipid Peroxidation/drug effects; Male; Mice; Mice, Inbred C57BL; Neuroblastoma/pathology; Oxidopamine/toxicity; Parkinsonian Disorders/chemically induced; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Piperazines / Parkinsonian Disorders / Aniline Compounds / Antioxidants Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Brain Res Year: 2008 Document type: Article

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