Molecular targeting of Bcl-2 overcomes prostate cancer cell adaptation to XIAP gene downregulation.

Nakano, Y; Bilim, V; Yuuki, K; Muto, A; Kato, T; Nagaoka, A; Tomita, Y

Nakano, Y; Bilim, V; Yuuki, K; Muto, A; Kato, T; Nagaoka, A; Tomita, Y.

Affiliation

Nakano Y; Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.

Prostate Cancer Prostatic Dis ; 12(1): 34-40, 2009.

Article in En | MEDLINE | ID: mdl-18475287

Subject(s)

Drug Resistance, Neoplasm/genetics; Prostatic Neoplasms/genetics; Proto-Oncogene Proteins c-bcl-2/genetics; X-Linked Inhibitor of Apoptosis Protein/genetics; Adaptation, Physiological; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Apoptosis/genetics; Blotting, Western; Cell Line, Tumor; Cisplatin/pharmacology; Down-Regulation; Gene Expression/drug effects; Humans; Male; Neoplasms, Hormone-Dependent/genetics; Neoplasms, Hormone-Dependent/metabolism; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms/metabolism; Proto-Oncogene Proteins c-bcl-2/drug effects; Proto-Oncogene Proteins c-bcl-2/metabolism; RNA Interference; Reverse Transcriptase Polymerase Chain Reaction; X-Linked Inhibitor of Apoptosis Protein/drug effects; X-Linked Inhibitor of Apoptosis Protein/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Prostatic Neoplasms / Drug Resistance, Neoplasm / Proto-Oncogene Proteins c-bcl-2 / X-Linked Inhibitor of Apoptosis Protein Limits: Humans / Male Language: En Journal: Prostate Cancer Prostatic Dis Year: 2009 Document type: Article

Fulltext

XML

PubMed Links

Search on Google