CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats.

Vandegriff, K D; Young, M A; Lohman, J; Bellelli, A; Samaja, M; Malavalli, A; Winslow, R M

Vandegriff, K D; Young, M A; Lohman, J; Bellelli, A; Samaja, M; Malavalli, A; Winslow, R M.

Affiliation

Vandegriff KD; Sangart, Inc., San Diego, CA 92121, USA. kvandegriff@sangart.com

Br J Pharmacol ; 154(8): 1649-61, 2008 Aug.

Article in En | MEDLINE | ID: mdl-18536756

Subject(s)

Carbon Monoxide/pharmacology; Hemoglobins/pharmacology; Maleimides/pharmacology; Myocardial Infarction/drug therapy; Polyethylene Glycols/pharmacology; Animals; Carbon Monoxide/administration & dosage; Carbon Monoxide/chemistry; Disease Models, Animal; Drug Stability; Erythrocytes/metabolism; Hemoglobins/administration & dosage; Hemoglobins/chemistry; Male; Maleimides/administration & dosage; Maleimides/chemistry; Myocardial Infarction/pathology; Myocardial Reperfusion Injury/physiopathology; Myocardial Reperfusion Injury/prevention & control; Polyethylene Glycols/administration & dosage; Polyethylene Glycols/chemistry; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Hemoglobins / Carbon Monoxide / Maleimides / Myocardial Infarction Limits: Animals Language: En Journal: Br J Pharmacol Year: 2008 Document type: Article

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