Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1.

Harrington, D J; Gorska, R; Wheeler, R; Davidson, S; Murden, S; Morse, C; Shearer, M J; Mumford, A D

Harrington, D J; Gorska, R; Wheeler, R; Davidson, S; Murden, S; Morse, C; Shearer, M J; Mumford, A D.

Affiliation

Harrington DJ; The Centre for Thrombosis and Haemostasis (Nutristasis Unit), Guy's and St Thomas' NHS Foundation Trust, London, UK.

J Thromb Haemost ; 6(10): 1663-70, 2008 Oct.

Article in En | MEDLINE | ID: mdl-18680536

Subject(s)

Drug Resistance; Mixed Function Oxygenases/genetics; Polymorphism, Single Nucleotide; Warfarin/pharmacokinetics; Biomarkers/blood; DNA Mutational Analysis; Humans; Oxidoreductases; Pharmacokinetics; Protein Precursors/blood; Prothrombin; Vitamin K Epoxide Reductases; Warfarin/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Warfarin / Drug Resistance / Polymorphism, Single Nucleotide / Mixed Function Oxygenases Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Thromb Haemost Year: 2008 Document type: Article

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