Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma.

Mao, X; Li, X; Sprangers, R; Wang, X; Venugopal, A; Wood, T; Zhang, Y; Kuntz, D A; Coe, E; Trudel, S; Rose, D; Batey, R A; Kay, L E; Schimmer, A D

Mao, X; Li, X; Sprangers, R; Wang, X; Venugopal, A; Wood, T; Zhang, Y; Kuntz, D A; Coe, E; Trudel, S; Rose, D; Batey, R A; Kay, L E; Schimmer, A D.

Leukemia ; 23(3): 585-90, 2009 Mar.

Article in En | MEDLINE | ID: mdl-18754030

Subject(s)

Antineoplastic Agents/pharmacology; Clioquinol/pharmacology; Leukemia, Experimental/drug therapy; Leukemia, Myeloid, Acute/enzymology; Multiple Myeloma/enzymology; Neoplasm Proteins/antagonists & inhibitors; Protease Inhibitors/pharmacology; Proteasome Inhibitors; Animals; Antineoplastic Agents/adverse effects; Antineoplastic Agents/therapeutic use; Archaeal Proteins/antagonists & inhibitors; Asian People; Cell Line, Tumor/drug effects; Cell Line, Tumor/enzymology; Clioquinol/adverse effects; Clioquinol/therapeutic use; Copper/antagonists & inhibitors; Copper/pharmacology; Drug Screening Assays, Antitumor; Endopeptidases; Humans; Japan; K562 Cells/drug effects; K562 Cells/enzymology; K562 Cells/transplantation; Leukemia, Experimental/enzymology; Leukemia, Myeloid, Acute/pathology; Mice; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma/pathology; Optic Nerve Diseases/chemically induced; Optic Nerve Diseases/ethnology; Protease Inhibitors/adverse effects; Protease Inhibitors/therapeutic use; Proteasome Endopeptidase Complex; Spinal Cord Diseases/chemically induced; Spinal Cord Diseases/ethnology; U937 Cells/drug effects; U937 Cells/enzymology; U937 Cells/transplantation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Leukemia, Myeloid, Acute / Leukemia, Experimental / Clioquinol / Proteasome Inhibitors / Multiple Myeloma / Neoplasm Proteins / Antineoplastic Agents Country/Region as subject: Asia Language: En Journal: Leukemia Year: 2009 Document type: Article

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