Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates.
Bioorg Med Chem
; 16(19): 8907-13, 2008 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-18789866
Synthesis of four glycolipids with different number of lauroyl groups on glucose or cellobiose as scaffolds is described. Their immunological evaluations either admixed with or covalently linked to J8, a peptide antigen derived from the C-terminus of the antiphagocytic M-protein of group A streptococcus, are also investigated. Administration of mixtures of J8 and glycolipids to B10BR (H-2(k)) mice induced low-levels of J8-specific IgG antibodies. While glycolipopeptides, in which J8 was covalently linked to the synthetic glycolipids, demonstrated high-levels of antibody titers comparable with the co-administration of these glycolipopeptides with complete Freund's adjuvant, suggesting clearly the strong potency of the synthesized glycolipids as self-adjuvanting moieties.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Streptococcus
/
Bacterial Vaccines
/
Glycolipids
/
Glycopeptides
/
Freund's Adjuvant
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem
Year:
2008
Document type:
Article